Glycan-Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies

An important class of HIV-1 broadly neutralizing antibodies, termed the VRC01-class, targets the conserved CD4-binding site (CD4bs) of the envelope glycoprotein (Env). An engineered Env outer domain (OD) eOD-GT8 60mer nanoparticle has been developed as a priming immunogen for eliciting VRC01-class p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Immunity
Prif Awduron: Duan, Hongying, Chen, Xuejun, Boyington, Jeffrey C., Cheng, Cheng, Zhang, Yi, Jafari, Alexander J., Stephens, Tyler, Tsybovsky, Yaroslav, Kalyuzhniy, Oleksandr, Zhao, Peng, Menis, Sergey, Nason, Martha C., Normandin, Erica, Mukhamedova, Maryam, Dekosky, Brandon, Wells, Lance, Schief, William R., Tian, Ming, Alt, Frederick, Kwong, Peter D., Mascola, John R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896779/
https://ncbi.nlm.nih.gov/pubmed/30076101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.07.005
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