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Glycan-Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies
An important class of HIV-1 broadly neutralizing antibodies, termed the VRC01-class, targets the conserved CD4-binding site (CD4bs) of the envelope glycoprotein (Env). An engineered Env outer domain (OD) eOD-GT8 60mer nanoparticle has been developed as a priming immunogen for eliciting VRC01-class p...
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| Published in: | Immunity |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6896779/ https://ncbi.nlm.nih.gov/pubmed/30076101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.07.005 |
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