Glycan-Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies

An important class of HIV-1 broadly neutralizing antibodies, termed the VRC01-class, targets the conserved CD4-binding site (CD4bs) of the envelope glycoprotein (Env). An engineered Env outer domain (OD) eOD-GT8 60mer nanoparticle has been developed as a priming immunogen for eliciting VRC01-class p...

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Bibliographic Details
Published in:Immunity
Main Authors: Duan, Hongying, Chen, Xuejun, Boyington, Jeffrey C., Cheng, Cheng, Zhang, Yi, Jafari, Alexander J., Stephens, Tyler, Tsybovsky, Yaroslav, Kalyuzhniy, Oleksandr, Zhao, Peng, Menis, Sergey, Nason, Martha C., Normandin, Erica, Mukhamedova, Maryam, Dekosky, Brandon, Wells, Lance, Schief, William R., Tian, Ming, Alt, Frederick, Kwong, Peter D., Mascola, John R.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896779/
https://ncbi.nlm.nih.gov/pubmed/30076101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.07.005
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