Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells

BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive phospholipid that acts as a signal transducer by binding to S1P receptors (S1PR) 1 to 5. The S1P/S1PRs pathway has been associated with remodeling and allergic inflammation in asthma, but the expression pattern of S1PR and its effects on non-i...

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Vydáno v:Respir Res
Hlavní autoři: Terashita, Tomomi, Kobayashi, Kazuyuki, Nagano, Tatsuya, Kawa, Yoshitaka, Tamura, Daisuke, Nakata, Kyosuke, Yamamoto, Masatsugu, Tachihara, Motoko, Kamiryo, Hiroshi, Nishimura, Yoshihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5103479/
https://ncbi.nlm.nih.gov/pubmed/27829417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-016-0465-x
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