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Elucidation of the glycosylation steps during biosynthesis of antitumor macrolides PM100117 and PM100118 and engineering for novel derivatives

BACKGROUND: Antitumor compounds PM100117 and PM100118 are glycosylated polyketides derived from the marine actinobacteria Streptomyces caniferus GUA-06-05-006A. The organization and characterization of the PM100117/18 biosynthesis gene cluster has been recently reported. RESULTS: Based on the preced...

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Pubblicato in:Microb Cell Fact
Autori principali: Salcedo, Raúl García, Olano, Carlos, Fernández, Rogelio, Braña, Alfredo F., Méndez, Carmen, de la Calle, Fernando, Salas, José A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5103430/
https://ncbi.nlm.nih.gov/pubmed/27829451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-016-0591-7
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