Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139

GPR139 is an orphan class A G protein-coupled receptor found mainly in the central nervous system. It has its highest expression levels in the hypothalamus and striatum, regions regulating metabolism and locomotion, respectively, and has therefore been suggested as a potential target for obesity and...

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Udgivet i:Sci Rep
Main Authors: Shehata, Mohamed A., Nøhr, Anne C., Lissa, Delphine, Bisig, Christoph, Isberg, Vignir, Andersen, Kirsten B., Harpsøe, Kasper, Björkling, Fredrik, Bräuner-Osborne, Hans, Gloriam, David E.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5103216/
https://ncbi.nlm.nih.gov/pubmed/27830715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36681
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