Pathogenic Helicobacter pylori Strains Translocate DNA and Activate TLR9 via the Cancer-Associated cag Type IV Secretion System

Helicobacter pylori is the strongest identified risk factor for gastric cancer, the third most common cause of cancer-related death worldwide. An H. pylori constituent that augments cancer risk is the strain-specific cag pathogenicity island, which encodes a type IV secretion system (T4SS) that tran...

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Publicado no:Oncogene
Main Authors: Varga, Matthew G., Shaffer, Carrie L., Sierra, Johanna C., Suarez, Giovanni, Piazuelo, M. Blanca, Whitaker, Morgan E., Romero-Gallo, Judith, Krishna, Uma S., Delgado, Alberto, Gomez, Martin A., Good, James A. D., Almqvist, Fredrik, Skaar, Eric P., Correa, Pelayo, Wilson, Keith T., Hadjifrangiskou, Maria, Peek, Richard M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5102820/
https://ncbi.nlm.nih.gov/pubmed/27157617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.158
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