HPV31 Utilizes the ATR-Chk1 Pathway to Maintain Elevated RRM2 Levels and a Replication-Competent Environment in Differentiating Keratinocytes

Productive replication of human papillomaviruses (HPV) is restricted to the uppermost layers of the differentiating epithelia. How HPV ensures an adequate supply of cellular substrates for viral DNA synthesis in a differentiating environment is unclear. Here, we demonstrate that HPV31 positive cells...

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Bibliographic Details
Published in:Virology
Main Authors: Anacker, Daniel C., Aloor, Heather L., Shepard, Caitlin N., Lenzi, Gina M., Johnson, Bryan A., Kim, Baek, Moody, Cary A.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5102796/
https://ncbi.nlm.nih.gov/pubmed/27764728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.09.028
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