Caspase-3 Deletion Promotes Necrosis in Atherosclerotic Plaques of ApoE Knockout Mice

Apoptosis of macrophages and vascular smooth muscle cells (VSMCs) in advanced atherosclerotic plaques contributes to plaque progression and instability. Caspase-3, a key executioner protease in the apoptotic pathway, has been identified in human and mouse atherosclerotic plaques but its role in athe...

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Publicado en:Oxid Med Cell Longev
Autores principales: Grootaert, Mandy O. J., Schrijvers, Dorien M., Hermans, Marthe, Van Hoof, Viviane O., De Meyer, Guido R. Y., Martinet, Wim
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101396/
https://ncbi.nlm.nih.gov/pubmed/27847551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/3087469
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