Domain-swapped T cell receptors improve the safety of TCR gene therapy

T cells engineered to express a tumor-specific αβ T cell receptor (TCR) mediate anti-tumor immunity. However, mispairing of the therapeutic αβ chains with endogenous αβ chains reduces therapeutic TCR surface expression and generates self-reactive TCRs. We report a general strategy to prevent TCR mis...

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Vydáno v:eLife
Hlavní autoři: Bethune, Michael T, Gee, Marvin H, Bunse, Mario, Lee, Mark S, Gschweng, Eric H, Pagadala, Meghana S, Zhou, Jing, Cheng, Donghui, Heath, James R, Kohn, Donald B, Kuhns, Michael S, Uckert, Wolfgang, Baltimore, David
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
Human Biology and Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101000/
https://ncbi.nlm.nih.gov/pubmed/27823582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19095
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