Domain-swapped T cell receptors improve the safety of TCR gene therapy

T cells engineered to express a tumor-specific αβ T cell receptor (TCR) mediate anti-tumor immunity. However, mispairing of the therapeutic αβ chains with endogenous αβ chains reduces therapeutic TCR surface expression and generates self-reactive TCRs. We report a general strategy to prevent TCR mis...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Bethune, Michael T, Gee, Marvin H, Bunse, Mario, Lee, Mark S, Gschweng, Eric H, Pagadala, Meghana S, Zhou, Jing, Cheng, Donghui, Heath, James R, Kohn, Donald B, Kuhns, Michael S, Uckert, Wolfgang, Baltimore, David
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2016
Konular:
Human Biology and Medicine
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101000/
https://ncbi.nlm.nih.gov/pubmed/27823582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19095
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