Domain-swapped T cell receptors improve the safety of TCR gene therapy

T cells engineered to express a tumor-specific αβ T cell receptor (TCR) mediate anti-tumor immunity. However, mispairing of the therapeutic αβ chains with endogenous αβ chains reduces therapeutic TCR surface expression and generates self-reactive TCRs. We report a general strategy to prevent TCR mis...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Bethune, Michael T, Gee, Marvin H, Bunse, Mario, Lee, Mark S, Gschweng, Eric H, Pagadala, Meghana S, Zhou, Jing, Cheng, Donghui, Heath, James R, Kohn, Donald B, Kuhns, Michael S, Uckert, Wolfgang, Baltimore, David
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2016
Onderwerpen:
Human Biology and Medicine
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101000/
https://ncbi.nlm.nih.gov/pubmed/27823582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19095
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items