SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC

The role of Sirtuin 6 (SIRT6) as a tumor suppressor or oncogene in liver cancer remains controversial. Thus, we identified the specific role of SIRT6 in the progression of hepatocellular carcinoma (HCC). SIRT6 expression was significantly higher in HCC cell lines and HCC tissues from 138 patients th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lee, Namgyu, Ryu, Hye Guk, Kwon, Jung-Hee, Kim, Dae-Kyum, Kim, Sae Rom, Wang, Hee Jung, Kim, Kyong-Tai, Choi, Kwan Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100879/
https://ncbi.nlm.nih.gov/pubmed/27824900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165835
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