SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC

The role of Sirtuin 6 (SIRT6) as a tumor suppressor or oncogene in liver cancer remains controversial. Thus, we identified the specific role of SIRT6 in the progression of hepatocellular carcinoma (HCC). SIRT6 expression was significantly higher in HCC cell lines and HCC tissues from 138 patients th...

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Vydáno v:PLoS One
Hlavní autoři: Lee, Namgyu, Ryu, Hye Guk, Kwon, Jung-Hee, Kim, Dae-Kyum, Kim, Sae Rom, Wang, Hee Jung, Kim, Kyong-Tai, Choi, Kwan Yong
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100879/
https://ncbi.nlm.nih.gov/pubmed/27824900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165835
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