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Grail controls Th2 cell development by targeting STAT6 for degradation
T helper (Th)-2 cells are the major players in allergic asthma; however, the mechanisms that control Th2-mediated inflammation are poorly understood. Here we find that enhanced expression of Grail, an E3 ubiquitin ligase, in Th2 cells depends on IL-4-signaling components, Stat6 and Gata3 that bind t...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5100808/ https://ncbi.nlm.nih.gov/pubmed/25145352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5732 |
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