Major and minor crRNA annealing sites facilitate low stringency DNA protospacer binding prior to Type I-A CRISPR-Cas interference in Sulfolobus

The stringency of crRNA-protospacer DNA base pair matching required for effective CRISPR-Cas interference is relatively low in crenarchaeal Sulfolobus species in contrast to that required in some bacteria. To understand its biological significance we studied crRNA-protospacer interactions in Sulfolo...

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Mousaei, Marzieh, Deng, Ling, She, Qunxin, Garrett, Roger A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100340/
https://ncbi.nlm.nih.gov/pubmed/27618562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2016.1229735
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