Efficient generation of GGTA1-null Diannan miniature pigs using TALENs combined with somatic cell nuclear transfer

BACKGROUND: α1,3-Galactosyltransferase (GGTA1) is essential for the biosynthesis of glycoproteins and therefore a simple and effective target for disrupting the expression of galactose α-1,3-galactose epitopes, which mediate hyperacute rejection (HAR) in xenotransplantation. Miniature pigs are consi...

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Detalhes bibliográficos
Publicado no:Reprod Biol Endocrinol
Main Authors: Cheng, Wenmin, Zhao, Heng, Yu, Honghao, Xin, Jige, Wang, Jia, Zeng, Luyao, Yuan, Zaimei, Qing, Yubo, Li, Honghui, Jia, Baoyu, Yang, Cejun, Shen, Youfeng, Zhao, Lu, Pan, Weirong, Zhao, Hong-Ye, Wang, Wei, Wei, Hong-Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100250/
https://ncbi.nlm.nih.gov/pubmed/27821126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12958-016-0212-7
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