Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation

Activation of human immune T-cells by swine leukocyte antigens class I (SLA-I) and class II (SLA-II) leads to xenograft destruction. Here, we generated the GGTA1, B2M, and CIITA (GBC) triple-gene-modified Diannan miniature pigs, analyzed the transcriptome of GBC-modified peripheral blood mononuclear...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kaixiang Xu, Honghao Yu, Shuhan Chen, Yaxuan Zhang, Jianxiong Guo, Chang Yang, Deling Jiao, Tien Dat Nguyen, Heng Zhao, Jiaoxiang Wang, Taiyun Wei, Honghui Li, Baoyu Jia, Muhammad Ameen Jamal, Hong-Ye Zhao, Xingxu Huang, Hong-Jiang Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
Colecção:Frontiers in Veterinary Science
Assuntos:
GGTA1
B2M
CIITA
major histocompatibility complex
pig
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fvets.2022.848833/full
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados