Recombinant L-asparaginase 1 from Saccharomyces cerevisiae: an allosteric enzyme with antineoplastic activity

L-asparaginase (L-ASNase) (EC 3.5.1.1) is an important enzyme for the treatment of acute lymphoblastic leukaemia. Currently, the enzyme is obtained from bacteria, Escherichia coli and Erwinia chrysanthemi. The bacterial enzymes family is subdivided in type I and type II; nevertheless, only type II h...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Costa, Iris Munhoz, Schultz, Leonardo, de Araujo Bianchi Pedra, Beatriz, Leite, Mariana Silva Moreira, Farsky, Sandra H. P., de Oliveira, Marcos Antonio, Pessoa, Adalberto, Monteiro, Gisele
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099943/
https://ncbi.nlm.nih.gov/pubmed/27824095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36239
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