Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation

The emergence of resistance to imatinib mediated by mutations in the BCR-ABL has become a major challenge in the treatment of chronic myeloid leukemia (CML). Alternative therapeutic strategies to override imatinib-resistant CML are urgently needed. In this study, we investigated the effect of AKI603...

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Pubblicato in:Sci Rep
Autori principali: Wang, Le-Xun, Wang, Jun-Dan, Chen, Jia-Jie, Long, Bing, Liu, Ling-Ling, Tu, Xi-Xiang, Luo, Yu, Hu, Yuan, Lin, Dong-Jun, Lu, Gui, Long, Zi-Jie, Liu, Quentin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099696/
https://ncbi.nlm.nih.gov/pubmed/27824120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35533
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