Comparative performance of oral midazolam clearance and plasma 4β‐hydroxycholesterol to explain interindividual variability in tacrolimus clearance

AIMS: We compared the CYP3A4 metrics weight‐corrected midazolam apparent oral clearance (MDZ Cl/F/W) and plasma 4β‐hydroxycholesterol/cholesterol (4β‐OHC/C) as they relate to tacrolimus (TAC) Cl/F/W in renal transplant recipients. METHODS: For a cohort of 147 patients, 8 h area under the curve (AUC)...

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Publicat a:Br J Clin Pharmacol
Autors principals: Vanhove, Thomas, de Jonge, Hylke, de Loor, Henriëtte, Annaert, Pieter, Diczfalusy, Ulf, Kuypers, Dirk R. J.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Pharmacokinetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099550/
https://ncbi.nlm.nih.gov/pubmed/27501475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13083
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