Influences of CYP2D6(*)10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis

AIM: Iloperidone is an atypical antipsychotic drug that is mainly metabolized by CYP2D6, CYP3A4, and cytosolic enzymes. Previous studies show that extensive and poor metabolizers of CYP2D6 exhibit different plasma concentrations of iloperidone and its metabolites. The aim of this study was to develo...

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Detalles Bibliográficos
Publicado en:Acta Pharmacol Sin
Main Authors: Pei, Qi, Huang, Lu, Huang, Jie, Gu, Jing-kai, Kuang, Yun, Zuo, Xiao-cong, Ding, Jun-jie, Tan, Hong-yi, Guo, Cheng-xian, Liu, Shi-kun, Yang, Guo-ping
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099419/
https://ncbi.nlm.nih.gov/pubmed/27665849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.96
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