DNA Methyltransferase Inhibitor Promotes Human CD4(+)CD25(h)FOXP3(+) Regulatory T Lymphocyte Induction under Suboptimal TCR Stimulation

The “master transcription factor” FOXP3 regulates the differentiation, homeostasis, and suppressor function of CD4(+) regulatory T (Treg) cells, which are critical in maintaining immune tolerance. Epigenetic regulation of FOXP3 expression has been demonstrated to be important to Treg cell developmen...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lu, Chun-Hao, Wu, Cheng-Jang, Chan, Cheng-Chi, Nguyen, Duc T., Lin, Kuo-Ray, Lin, Syh-Jae, Chen, Li-Chen, Yen, Jeffrey Jong-Yong, Kuo, Ming-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099256/
https://ncbi.nlm.nih.gov/pubmed/27877174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00488
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