Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4(+)CD25(- )T cells

BACKGROUND: CD4(+)CD25(+ )T regulatory cells (Tregs) play an important role in regulating immune responses, and in influencing human immune diseases such as HIV infection. It has been shown that human CD4(+)CD25(+ )Tregs can be induced in vitro by TCR stimulation of CD4(+)CD25(- )T cells. However, t...

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Hlavní autoři: Amarnath, Shoba, Dong, Li, Li, Jun, Wu, Yuntao, Chen, WanJun
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2007
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2096626/
https://ncbi.nlm.nih.gov/pubmed/17688698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-4-57
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