Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures

This paper shows that the effects of causal SNPs on lifespan, estimated through GWAS, may be confounded and the genetic structure of the study population may be responsible for this effect. Simulation experiments show that levels of linkage disequilibrium (LD) and other parameters of the population...

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Vydáno v:Front Genet
Hlavní autoři: Yashin, Anatoliy I., Zhbannikov, Ilya, Arbeeva, Liubov, Arbeev, Konstantin G., Wu, Deqing, Akushevich, Igor, Yashkin, Arseniy, Kovtun, Mikhail, Kulminski, Alexander M., Stallard, Eric, Kulminskaya, Irina, Ukraintseva, Svetlana
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099244/
https://ncbi.nlm.nih.gov/pubmed/27877192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2016.00188
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