Puzzling role of genetic risk factors in human longevity: “risk alleles” as pro-longevity variants

Complex diseases are major contributors to human mortality in old age. Paradoxically, many genetic variants that have been associated with increased risks of such diseases are found in genomes of long-lived people, and do not seem to compromise longevity. Here we argue that trade-off-like and condit...

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Bibliografiske detaljer
Udgivet i:Biogerontology
Main Authors: Ukraintseva, Svetlana, Yashin, Anatoliy, Arbeev, Konstantin, Kulminski, Alexander, Akushevich, Igor, Wu, Deqing, Joshi, Gaurang, Land, Kenneth C., Stallard, Eric
Format: Artigo
Sprog:Inglês
Udgivet: Springer Netherlands 2015
Fag:
Review Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724477/
https://ncbi.nlm.nih.gov/pubmed/26306600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10522-015-9600-1
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