Association of Cytochrome P450 Genetic Variants with Clopidogrel Resistance and Outcomes in Acute Ischemic Stroke

Aims: Clopidogrel is an antiplatelet drug primarily used to treat or prevent acute ischemic stroke (IS) or myocardial infarction (MI). This prodrug requires biotransformation to an active metabolite by cytochrome P450 (CYP) enzymes, and CYP single nucleotide polymorphisms (SNPs) could affect the eff...

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Publicado en:J Atheroscler Thromb
Autores principales: Yi, Xingyang, Lin, Jing, Wang, Yanfen, Zhou, Qiang, Wang, Chun, Cheng, Wen, Chi, Lifen
Formato: Artigo
Lenguaje:Inglês
Publicado: Japan Atherosclerosis Society 2016
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098919/
https://ncbi.nlm.nih.gov/pubmed/26961113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5551/jat.33290
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