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Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors
In humans, errors in meiotic chromosome segregation that produce aneuploid gametes increase dramatically as women age, a phenomenon termed the “maternal age effect.” During meiosis, cohesion between sister chromatids keeps recombinant homologs physically attached and premature loss of cohesion can l...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5098651/ https://ncbi.nlm.nih.gov/pubmed/27791141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612047113 |
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