Pyrrole-Derivative of Chalcone, (E)-3-Phenyl-1-(2-Pyrrolyl)-2-Propenone, Inhibits Inflammatory Responses via Inhibition of Src, Syk, and TAK1 Kinase Activities

(E)-3-Phenyl-1-(2-pyrrolyl)-2-propenone (PPP) is a pyrrole derivative of chalcone, in which the B-ring of chalcone linked to β-carbon is replaced by pyrrole group. While pyrrole has been studied for possible Src inhibition activity, chalcone, especially the substituents on the B-ring, has shown phar...

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Vydáno v:Biomol Ther (Seoul)
Hlavní autoři: Yang, Sungjae, Kim, Yong, Jeong, Deok, Kim, Jun Ho, Kim, Sunggyu, Son, Young-Jin, Yoo, Byong Chul, Jeong, Eun Jeong, Kim, Tae Woong, Lee, In-Sook Han, Cho, Jae Youl
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Society of Applied Pharmacology 2016
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098538/
https://ncbi.nlm.nih.gov/pubmed/27469142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2016.027
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