Charge heterogeneity: Basic antibody charge variants with increased binding to Fc receptors

We identified active isoforms of the chimeric anti-GD2 antibody, ch14.18, a recombinant antibody produced in Chinese hamster ovary cells, which is already used in clinical trials.(1,2,3) We separated the antibody by high resolution ion-exchange chromatography with linear pH gradient elution into aci...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:MAbs
Hauptverfasser: Hintersteiner, Beate, Lingg, Nico, Zhang, Peiqing, Woen, Susanto, Hoi, Kong Meng, Stranner, Stefan, Wiederkum, Susanne, Mutschlechner, Oliver, Schuster, Manfred, Loibner, Hans, Jungbauer, Alois
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2016
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098448/
https://ncbi.nlm.nih.gov/pubmed/27559765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1225642
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge