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A phase 1 study of KOS-862 (Epothilone D) co-administered with carboplatin (Paraplatin(®)) in patients with advanced solid tumors
PURPOSE: To determine the maximally tolerated dose (MTD) and pharmacokinetics of carboplatin plus KOS-862 (Epothilone D) a novel cytotoxic macrolide capable of causing mitotic arrest, in patients with advanced solid malignancies. EXPERIMENTAL DESIGN: Patients who have progressed on standard regimens...
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| Publicado no: | Invest New Drugs |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5098268/ https://ncbi.nlm.nih.gov/pubmed/21826439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-011-9731-4 |
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