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Phase I dose escalation study of KOS-1584, a novel epothilone, in patients with advanced solid tumors
PURPOSE: First-in-man study of KOS-1584, a second generation epothilone. METHODS: Patients with advanced solid malignancies received KOS-1584 every 3 weeks until disease progression. Using a modified Fibonacci dose escalation scheme, one patient was enrolled at each dose level until the first instan...
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| Principais autores: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3865603/ https://ncbi.nlm.nih.gov/pubmed/21874318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1724-7 |
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