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Targeted in vivo delivery of EGFR siRNA inhibits ovarian cancer growth and enhances drug sensitivity

A functionalized nanohydrogel siRNA delivery system and a mouse model of serous ovarian cancer were used to test predictions from previous cell line studies that knockdown of EGFR (epidermal growth factor receptor) may be of clinical significance in the treatment of epithelial tumors especially with...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Satpathy, Minati, Mezencev, Roman, Wang, Lijuan, McDonald, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098171/
https://ncbi.nlm.nih.gov/pubmed/27819259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36518
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