Celecoxib alleviates oxaliplatin-induced hyperalgesia through inhibition of spinal ERK1/2 signaling

Numerous pieces of evidence have revealed that oxaliplatin (OXA) evokes mechanical and cold hypersensitivity. However, the mechanism underlying these bothersome side effects needs to be further investigated. It is well known that cyclooxygenase-2 (COX-2) and extracellular signal-regulated kinases (E...

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Gepubliceerd in:J Toxicol Pathol
Hoofdauteurs: Chen, Hongping, Wang, Qinghua, Shi, Danni, Yao, Dongbo, Zhang, Lei, Xiong, Junping, Xu, Baohua
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Japanese Society of Toxicologic Pathology 2016
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097968/
https://ncbi.nlm.nih.gov/pubmed/27821910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.2016-0032
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