The “Lid” in the Streptococcus Pneumoniae SrtC1 Sortase Adopts a Rigid Structure that Regulates Substrate Access to the Active Site

Many species of Gram-positive bacteria use sortase enzymes to assemble long, proteinaceous pili structures that project from the cell surface to mediate microbial adhesion. Sortases construct highly stable structures by catalyzing a transpeptidation reaction that covalently links pilin subunits toge...

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Bibliographic Details
Published in:J Phys Chem B
Main Authors: Jacobitz, Alex W., Naziga, Emmanuel B., Yi, Sung Wook, McConnell, Scott A., Peterson, Robert, Jung, Michael E., Clubb, Robert T., Wereszczynski, Jeff
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097456/
https://ncbi.nlm.nih.gov/pubmed/27109553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b01930
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