Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres

Centromeres are specified epigenetically through the deposition of the centromere-specific histone H3 variant CENP-A. However, how additional epigenetic features are involved in centromere specification is unknown. Here, we find that histone H4 Lys5 and Lys12 acetylation (H4K5ac and H4K12ac) primari...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Shang, Wei-Hao, Hori, Tetsuya, Westhorpe, Frederick G., Godek, Kristina M., Toyoda, Atsushi, Misu, Sadahiko, Monma, Norikazu, Ikeo, Kazuho, Carroll, Christopher W., Takami, Yasunari, Fujiyama, Asao, Kimura, Hiroshi, Straight, Aaron F., Fukagawa, Tatsuo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097169/
https://ncbi.nlm.nih.gov/pubmed/27811920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13465
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