Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual-Targeting in Patient-Derived 3D Pancreatic Cancer Models

Pancreatic ductal adenocarcinoma (PDAC) is the 4(th) leading cause of cancer-related mortality in the United States. Aggressive treatment regimens have not changed the disease course, and the median survival has just recently reached a year. Several mechanisms are proposed to play a role in PDAC the...

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Udgivet i:Mol Cancer Ther
Main Authors: Logsdon, Derek P., Grimard, Michelle, Luo, Meihua, Shahda, Safi, Jiang, Yanlin, Tong, Yan, Yu, Zhangsheng, Zyromski, Nicholas, Schipani, Ernestina, Carta, Fabrizio, Supuran, Claudiu T., Korc, Murray, Ivan, Mircea, Kelley, Mark R., Fishel, Melissa L.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097013/
https://ncbi.nlm.nih.gov/pubmed/27535970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0253
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