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Spinal astrocytic thrombospondin-4 induced by excitatory neuronal signaling mediates pain after facet capsule injury

Thrombospondin-4 (TSP4) is a synaptogenic molecule that is upregulated in the spinal cord after painful facet joint injury and may contribute to spinal hyperexcitability. However, the mechanisms leading to increased spinal TSP4 are unclear. Because primary afferent activity is critical in the develo...

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Détails bibliographiques
Publié dans:Ann Biomed Eng
Auteurs principaux: Crosby, Nathan D., Winkelstein, Beth A.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096960/
https://ncbi.nlm.nih.gov/pubmed/27160673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10439-016-1639-x
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