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Gabapentin alleviates facet-mediated pain in the rat through reduced neuronal hyperexcitability and astrocytic activation in the spinal cord

Although joint pain is common, its mechanism(s) remain undefined, with little known about the spinal neuronal responses that contribute to this type of pain. Afferent activity and sustained spinal neuronal hyperexcitability correlate to facet joint loading and the extent of behavioral sensitivity in...

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Autori principali: Dong, Ling, Crosby, Nathan D., Winkelstein, Beth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849122/
https://ncbi.nlm.nih.gov/pubmed/24094695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2013.07.016
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