Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice

Radiotherapy causes dose-limiting toxicity and long-term complications in rapidly renewing tissues, including the gastrointestinal tract. Currently, there is no FDA-approved agent for the prevention or treatment of radiation-induced intestinal injury. In this study, we have shown that PD 0332991 (PD...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Wei, Liang, Leibowitz, Brian J., Wang, Xinwei, Epperly, Michael, Greenberger, Joel, Zhang, Lin, Yu, Jian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096907/
https://ncbi.nlm.nih.gov/pubmed/27701148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88410
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