Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation

Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we demonstrated that p53 target PUMA mediates radiation-induced apoptosis via a cell-intrinsic mechanism, and identified the GSK-3 i...

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Foilsithe in:Sci Rep
Main Authors: Wang, Xinwei, Wei, Liang, Cramer, Julie M., Leibowitz, Brian J., Judge, Colleen, Epperly, Michael, Greenberger, Joel, Wang, Fengchao, Li, Linheng, Stelzner, Matthias G., Dunn, James C. Y., Martin, Martin G., Lagasse, Eric, Zhang, Lin, Yu, Jian
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392360/
https://ncbi.nlm.nih.gov/pubmed/25858503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08566
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