Insulin receptor Thr(1160) phosphorylation mediates lipid-induced hepatic insulin resistance

Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes (T2D), but whether NAFLD plays a causal role in the pathogenesis of T2D is uncertain. One proposed mechanism linking NAFLD to hepatic insulin resistance involves diacylglycerol-mediated (DAG-mediated) activation of protein...

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Pubblicato in:J Clin Invest
Autori principali: Petersen, Max C., Madiraju, Anila K., Gassaway, Brandon M., Marcel, Michael, Nasiri, Ali R., Butrico, Gina, Marcucci, Melissa J., Zhang, Dongyan, Abulizi, Abudukadier, Zhang, Xian-Man, Philbrick, William, Hubbard, Stevan R., Jurczak, Michael J., Samuel, Varman T., Rinehart, Jesse, Shulman, Gerald I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096902/
https://ncbi.nlm.nih.gov/pubmed/27760050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86013
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