Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions

Loss-of-function mutations in the BRCA1 and BRCA2 genes increase the risk of cancer. Owing to their function in homologous recombination repair, much research has focused on the unstable genomic phenotype of BRCA1/2 mutant cells manifest mainly as large-scale rearrangements. We used whole-genome seq...

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Detalles Bibliográficos
Publicado en:Oncogene
Main Authors: Zámborszky, J, Szikriszt, B, Gervai, J Z, Pipek, O, Póti, Á, Krzystanek, M, Ribli, D, Szalai-Gindl, J M, Csabai, I, Szallasi, Z, Swanton, C, Richardson, A L, Szüts, D
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
Assuntos:
Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096687/
https://ncbi.nlm.nih.gov/pubmed/27452521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.243
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