Laboratory‐Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme‐Catalyzed Epoxide Hydrolysis

Engineered enzyme variants of potato epoxide hydrolase (StEH1) display varying degrees of enrichment of (2R)‐3‐phenylpropane‐1,2‐diol from racemic benzyloxirane. Curiously, the observed increase in the enantiomeric excess of the (R)‐diol is not only a consequence of changes in enantioselectivity for...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Janfalk Carlsson, Åsa, Bauer, Paul, Dobritzsch, Doreen, Nilsson, Mikael, Kamerlin, S. C. Lynn, Widersten, Mikael
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096066/
https://ncbi.nlm.nih.gov/pubmed/27383542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600330
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