Laboratory‐Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme‐Catalyzed Epoxide Hydrolysis

Engineered enzyme variants of potato epoxide hydrolase (StEH1) display varying degrees of enrichment of (2R)‐3‐phenylpropane‐1,2‐diol from racemic benzyloxirane. Curiously, the observed increase in the enantiomeric excess of the (R)‐diol is not only a consequence of changes in enantioselectivity for...

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Detaylı Bibliyografya
Yayımlandı:Chembiochem
Asıl Yazarlar: Janfalk Carlsson, Åsa, Bauer, Paul, Dobritzsch, Doreen, Nilsson, Mikael, Kamerlin, S. C. Lynn, Widersten, Mikael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2016
Konular:
Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096066/
https://ncbi.nlm.nih.gov/pubmed/27383542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600330
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