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Import of a major mitochondrial enzyme depends on synergy between two distinct helices of its presequence
Mammalian glutamate dehydrogenase (GDH), a nuclear-encoded enzyme central to cellular metabolism, is among the most abundant mitochondrial proteins (constituting up to 10% of matrix proteins). To attain such high levels, GDH depends on very efficient mitochondrial targeting that, for human isoenzyme...
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| Publicado no: | Biochem J |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5095901/ https://ncbi.nlm.nih.gov/pubmed/27422783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160535 |
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