The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit

Regulation of the epithelial sodium channel (ENaC), which regulates fluid homeostasis and blood pressure, is complex and remains incompletely understood. The TIP peptide, a mimic of the lectin-like domain of TNF, activates ENaC by binding to glycosylated residues in the extracellular loop of ENaC-α,...

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Publicat a:J Biol Chem
Autors principals: Lucas, Rudolf, Yue, Qiang, Alli, Abdel, Duke, Billie Jeanne, Al-Khalili, Otor, Thai, Tiffany L., Hamacher, Jürg, Sridhar, Supriya, Lebedyeva, Iryna, Su, Huabo, Tzotzos, Susan, Fischer, Bernhard, Gameiro, Armanda Formigao, Loose, Maria, Chakraborty, Trinad, Shabbir, Waheed, Aufy, Mohammed, Lemmens-Gruber, Rosa, Eaton, Douglas C., Czikora, Istvan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095400/
https://ncbi.nlm.nih.gov/pubmed/27645999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.718163
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