Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism

Benzylisoquinoline alkaloids (BIAs) are produced in a wide variety of plants and include many common analgesic, antitussive, and anticancer compounds. Several members of a distinct family of S-adenosylmethionine (SAM)-dependent N-methyltransferases (NMTs) play critical roles in BIA biosynthesis, but...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Torres, Miguel A., Hoffarth, Elesha, Eugenio, Luiz, Savtchouk, Julia, Chen, Xue, Morris, Jeremy S., Facchini, Peter J., Ng, Kenneth K.-S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095397/
https://ncbi.nlm.nih.gov/pubmed/27573242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.747261
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