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Recombinant fusion protein identified by lepromatous sera mimics native Mycobacterium leprae in T-cell responses across the leprosy spectrum.

Pooled polyvalent sera from lepromatous leprosy patients were used to screen a lambda gt11 recombinant DNA expression library of Mycobacterium leprae in order to identify the relevant antigens recognized by the human immune response. Of the 300,000 phages screened, 4 clones were identified that code...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Laal, S, Sharma, Y D, Prasad, H K, Murtaza, A, Singh, S, Tangri, S, Misra, R S, Nath, I
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50953/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1992456/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.3.1054
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