Suppression of GLI sensitizes medulloblastoma cells to mitochondria-mediated apoptosis

PURPOSE: The sonic hedgehog (SHH) signalling pathway plays the important role in medulloblastoma (MB). Altered GLI expression plays a key role in these processes, and the inhibition of GLI may be a good cancer-targeted therapy. This study aimed to investigate whether GANT61, a GLI inhibitor, may inh...

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Publicat a:J Cancer Res Clin Oncol
Autors principals: Lin, Zhongxiao, Li, Sisi, Sheng, Hansong, Cai, Ming, Ma, Lin Yuan Si, Hu, Liuxun, Xu, Shangyu, Yu, Li Sheng, Zhang, Nu
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2016
Matèries:
Original Article – Cancer Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095157/
https://ncbi.nlm.nih.gov/pubmed/27601167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-016-2241-1
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