Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

The glutamate transporter xCT (SCL7a11, system Xc-, SXC) is an emerging key player in glutamate/cysteine/glutathione homeostasis in the brain and in cancer. xCT expression correlates with the grade of malignancy. Here, we report on the use of the U.S. Food and Drug Administration and EMA-approved xC...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Sehm, Tina, Fan, Zheng, Ghoochani, Ali, Rauh, Manfred, Engelhorn, Tobias, Minakaki, Georgia, Dörfler, Arnd, Klucken, Jochen, Buchfelder, Michael, Eyüpoglu, Ilker Y., Savaskan, Nicolai
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094980/
https://ncbi.nlm.nih.gov/pubmed/27074570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8651
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