The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia

The histone methyltransferase EZH2 induces gene repression through trimethylation of histone H3 at lysine 27 (H3K27me3). EZH2 overexpression has been reported in many types of cancer and associated with poor prognosis. Here we investigated the expression and functionality of EZH2 in chronic lymphocy...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Papakonstantinou, Nikos, Ntoufa, Stavroula, Chartomatsidou, Elisavet, Kotta, Konstantia, Agathangelidis, Andreas, Giassafaki, Lefki, Karamanli, Tzeni, Bele, Panagiota, Moysiadis, Theodoros, Baliakas, Panagiotis, Sutton, Lesley Ann, Stavroyianni, Niki, Anagnostopoulos, Achilles, Makris, Antonios M., Ghia, Paolo, Rosenquist, Richard, Stamatopoulos, Kostas
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094974/
https://ncbi.nlm.nih.gov/pubmed/27191993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9371
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