Genome-wide profiles of extra-cranial malignant rhabdoid tumors reveal heterogeneity and dysregulated developmental pathways

Malignant rhabdoid tumors (MRT) are rare, lethal tumors of childhood that most commonly occur in the kidney and brain. MRT are driven by SMARCB1 loss, but the molecular consequences of SMARCB1 loss in extra-cranial tumors have not been comprehensively described and genomic resources for analyses of...

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Publicado no:Cancer Cell
Main Authors: Chun, Hye-Jung E., Lim, Emilia L., Heravi-Moussavi, Alireza, Saberi, Saeed, Mungall, Karen L., Bilenky, Mikhail, Carles, Annaick, Tse, Kane, Shlafman, Inna, Zhu, Kelsey, Qian, Jenny Q., Palmquist, Diana L., He, An, Long, William, Goya, Rodrigo, Ng, Michelle, LeBlanc, Veronique G., Pleasance, Erin, Thiessen, Nina, Wong, Tina, Chuah, Eric, Zhao, Yong-Jun, Schein, Jacquie E., Gerhard, Daniela S., Taylor, Michael D., Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Jones, Steven J.M., Perlman, Elizabeth J., Hirst, Martin, Marra, Marco A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094835/
https://ncbi.nlm.nih.gov/pubmed/26977886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.02.009
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