FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins.

FK 506, a powerful immunosuppressant that blocks allograft rejection by preventing T-cell activation, binds to an 11-kDa protein called the FK 506-binding protein (FKBP). Like cyclophilin, a cytosolic protein that binds another immunosuppressant, cyclosporin A, FKBP possesses peptidylprolyl cis-tran...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Wiederrecht, G, Brizuela, L, Elliston, K, Sigal, N H, Siekierka, J J
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 1991
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50948/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1704127/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.3.1029
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